How common is PKD?
In the United States about 600,000 people have PKD. It is the fourth leading cause of kidney failure. If is found in all races and occurs equally in men and women. It causes about 5% of all kidney failure.
What other organs besides the kidney are affected by PKD?
PKD can affect other organs besides the kidney. People with PKD may have cysts in their liver, pancreas, spleen, ovaries, and large bowel. Cysts in these organs usually do not cause serious problems, but can in some people. PKD can also affect the brain or heart. If PKD affects the brain, it can cause an aneurysm. An aneurysm is a bulging blood vessel that can burst, resulting in a stroke or even death. If PKD affects the heart, the valves can become floppy, resulting in a heart murmur in some patients.
What are the clues that someone has PKD?
Most people do not develop symptoms until they are 30 to 40 years old. The first noticeable signs and symptoms may include:
- Back or side pain
- An increase in the size of the abdomen
- Blood in the urine
- Frequent bladder or kidney infections
- High blood pressure
High blood pressure is the most common sign of PKD. Occasionally, patients may develop headaches related to high blood pressure or their doctors may detect high blood pressure during a routine physical exam. Because high blood pressure can cause kidney damage, it is very important to treat it. In fact, treatment of high blood pressure can help slow or even prevent kidney failure.
- Fluttering or pounding in the chest
About 25% of PKD patients have a so-called floppy valve in the heart, and may experience a fluttering or pounding in the chest as well as chest pain. These symptoms almost always disappear on their own but may be the first hint that someone has PKD.
How is PKD diagnosed?
Ultrasound is the most reliable, inexpensive and non-invasive way to diagnose PKD. If someone at risk for PKD is older than 30 years and has a normal ultrasound of the kidneys, he or she probably does not have PKD. Occasionally, a CT scan (computed tomography scan) and MRI (magnetic resonance imaging) may detect smaller cysts that cannot be found by an ultrasound. MRI is used to measure and monitor volume and growth of kidneys and cysts.
At present, PKD cannot be diagnosed by a single blood test. However, in some situations where it is important to have a diagnosis (for example, if a family member wants to donate a kidney to an affected parent or sibling, and ultrasound and CT scans are normal), special blood tests on at least three family members can be done to get a diagnosis in the at-risk individual. This form of testing is called gene linkage analysis.
Does everyone with PKD develop kidney failure?
No. About 50 percent of people with PKD will have kidney failure by age 60, and about 60 percent will have kidney failure by age 70. People with kidney failure will need dialysis or a kidney transplant. Certain people have an increased risk of kidney failure including:
- patients with high blood pressure
- patients with protein or blood in their urine
- women with high blood pressure who have had more than three pregnancies
How is PKD treated?
At present, there is no cure for PKD. However, a lot of research is being done. Many studies suggest that some treatments may slow the rate of kidney disease in PKD, but further research is needed before these treatments can be used in patients. Other studies are helping us understand the genetic basis of PKD.
In the meantime, many supportive treatments can be done to help prevent or slow down the loss of kidney function in people with PKD and control symptoms. These include:
- careful control of blood pressure
- prompt treatment with antibiotics of a bladder or kidney infection
- lots of fluid when blood in the urine is first noted
- medication to control pain (talk to your doctor about which over-the-counter medicines are safe to take if you have kidney disease)
- a healthy lifestyle with regard to smoking cessation, exercise, weight control and reduced salt intake
Should people with PKD take a special diet?
At present, no specific diet is known to prevent cysts from developing in patients with PKD. Reducing salt intake helps control blood pressure in PKD patients who have high blood pressure. A diet low in fat and moderate in calories is recommended to maintain a healthy weight. Speak to your doctor about other changes to your diet, such as avoiding caffine.
Is exercise recommended for people with PKD?
Absolutely. However, exercises that are potentially harmful to the kidney, such as contact sports, should be avoided. It is important not to become too dehydrated during any physical activity.
Who is at risk for developing PKD?
PKD runs in families. It is an inherited disorder that is passed from parents to children through genes. Genes are the basic elements of heredity. At conception, children receive a set of genes from each parent. They determine many characteristics such as hair color and eye color. Genes can also determine the likelihood of developing a disease.
A genetic disease can happen if one or both parents pass abnormal genes to a child. This happens through something called dominant inheritance or recessive inheritance..
If one parent has the disease and passes an abnormal gene to the child, it is called dominant inheritance. Each child has a 50% chance of getting the disease. The risk is the same for every child, regardless of how many children develop the disease.
If both parents carry the abnormal gene, and both parents pass an abnormal gene to the child, it is called recessive inheritance. In this situation, every child has a 25% chance of getting the disease.
Are there different types of PKD?
Yes. The three main types of PKD are:
- Autosomal Dominant PKD (also called PKD or ADPKD). This form of the disease is passed from parent to child by dominant inheritance. In other words, only one copy of the abnormal gene is needed to cause the disease. Symptoms usually begin between the ages of 30 and 40, but they can begin earlier, even in childhood. ADPKD is the most common form of PKD. In fact, about 90 percent of all PKD cases are ADPKD.
- Infantile or Autosomal Recessive PKD (also called ARPKD). This form of the disease is passed from parent to child by recessive inheritance. Symptoms can begin in the earliest months of life, even in the womb. It tends to be very serious, progresses rapidly, and is often fatal in the first few months of life. This form of ARPKD is extremely rare. It occurs in 1 out of 25,000 people.
- Acquired Cystic Kidney Disease (also called ACKD). ACKD can happen in kidneys with long-term damage and severe scarring, so it is often associated with kidney failure and dialysis. About 90 percent of people on dialysis for 5 years develop ACKD. People with ACKD usually seek help because they notice blood in their urine. This is because the cysts bleed into the urinary system, which discolors urine.
Should people with PKD have children?
Individuals with PKD who are concerned about passing the disease to their children may want to consult a genetics counselor to help them with family planning. Many university medical centers have this service.
Should women with PKD get pregnant?
Most of the women with PKD (80 percent) have successful and uneventful pregnancies. However, some women with PKD have an increased risk for serious complications for themselves and their babies. This includes women with PKD who also have:
- high blood pressure
- decreased kidney function
Women who have PKD with high blood pressure develop pre-eclampsia (or toxemia) in 40 percent of pregnancies. This is a life-threatening disorder for both the mother and baby, and it can develop suddenly and without warning. Therefore, all women with PKD, particularly those who also have high blood pressure, should be followed closely during their pregnancy by their doctor.
What research is being done on PKD?
PKD is a very active area of research at present. This is a very exciting time in the field and there are several ongoing trials for new treatments. Some of the questions being investigated are:
- What changes occur in the ADPKD genes?
- What is the function of polycystin, a protein that may be associated with the development of PKD?
- What makes kidney cysts grow?
- What is the best level of blood pressure control for PKD patients?
- What is the best type of blood pressure medication for PKD patients?
- Do aneurysms in PKD patients grow? How fast do they grow?
- Can cyst growth be delayed or prevented with special drugs?
If you or a family member is interested in joining a trial, you should contact the Polycystic Kidney Disease Foundation at 1-800-PKD-CURE.
What if I have more questions?
If you have more questions, you should speak to your doctor. You can also get more information from:
Polycystic Kidney Disease Foundation
4901 Main Street, Suite 200
Kansas City, MO 64112-2634
Or contact the Northeast Kidney Foundation at (800) 999-9697 or email firstname.lastname@example.org
This material is intended for informational purposes only and does not constitute medical advice. Medical questions cannot be answered via email. Please consult a physician for specific treatment recommendations. Information above was provided by the National Kidney Foundation and is subject to copyright restrictions. One copy may be printed for personal use.